Authors
Ophira Salomon, Ruth Huna-Baron, Shimon Kurtz, David M Steinberg, Joseph Moisseiev, Nurit Rosenberg, Iftach Yassur, Orit Vidne, Ariella Zivelin, Sanford Gitel, Jacqueline Davidson, Bruria Ravid, Uri Seligsohn
Publication date
1999/4/1
Journal
Ophthalmology
Volume
106
Issue
4
Pages
739-742
Publisher
Elsevier
Description
OBJECTIVE
To determine whether genetic or acquired thrombophilias and other risk factors are associated with nonarteritic anterior ischemic optic neuropathy (NAION).
DESIGN
Retrospective case-control study.
PARTICIPANTS
Sixty-one patients with NAION diagnosed between 1984 and 1997. Ninety consecutive patients who visited the Eye Institute made up the control group.
INTERVENTION
Protein C, protein S, antithrombin III, lupus anticoagulant, and three recently described prothrombotic polymorphisms (i.e., factor V G1691A, factor II G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T) were analyzed. In addition, risk factors for arteriosclerotic vascular disease were assessed.
MAIN OUTCOME MEASURES
Parameters of thrombophilia.
RESULTS
None of the thrombophilic markers (genetic and acquired) constituted a significant risk factor for NAION. Ischemic heart disease …
Total citations
Scholar articles
O Salomon, R Huna-Baron, S Kurtz, DM Steinberg… - Ophthalmology, 1999