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SRAM-based FPGA devices have been used widely in many industrial domains, but only limitedly in secure and safety-critical applications, which have special requirements for the physical implementation, such as module isolation. This is partly due to limited functionality available with current FPGA vendors' tools and flows. To extend FPGA's appearance in secure and safety-critical applications, we propose an alternative flow for isolation design called the Isolated Partial Reconfiguration Design Flow (IPRDF) in this paper. Systems designed by the proposed IPRDF are not only fully isolated but also support partial reconfiguration of insulated modules. This allows building secure and dependable systems that can use partial reconfiguration to mitigate from single-event upsets (SEUs) and that are more tolerant to aging and device imperfections. Further, this also allows information assurance applications to benefit …