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Evolving technology and advances in medical knowledge mandate a need to update these guidelines. The aim of this report is to assist physicians throughout the world in referring potential candidates for lung transplantation. It is important to recognize that few data exist from randomized controlled trials upon which to support the recommendations outlined in this report. Therefore, these guidelines are based primarily on a consensus of opinion rendered by experts in the field and on analysis of retrospective single-center, multicenter, and multinational registries. These guidelines must remain a general statement of suitability, as further advances in knowledge and different societal values, specific local expertise, and donor allocation systems demand some flexibility. Lung transplantation is now a generally accepted therapy for the management of a wide range of severe lung disorders, with evidence supporting …