Authors
NICE-SUGAR Study Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group sfinfer@ georgeinstitute. org. au
Publication date
2015/6
Journal
Intensive care medicine
Volume
41
Pages
1037-1047
Publisher
Springer Berlin Heidelberg
Description
Purpose
To compare the effect of intensive versus conventional blood glucose control in patients with traumatic brain injury.
Methods
In a large international randomized trial patients were randomly assigned to a target blood glucose (BG) range of either 4.5–6.0 mmol/L (intensive control) or <10 mmol/L (conventional control). Patients with traumatic brain injury (TBI) were identified at randomization and data were collected to examine the extended Glasgow outcome score (includes mortality) at 24 months.
Results
Of the 6104 randomized patients, 391 satisfied diagnostic criteria for TBI; 203 (51.9 %) were assigned to intensive and 188 (48.1 %) to conventional control; the primary outcome was available for 166 (81.8 %) and 149 (79.3 %) patients, respectively. The two groups had
similar baseline characteristics …
Scholar articles
NICE-SUGAR Study Investigators for the Australian … - Intensive care medicine, 2015