Authors
Simon Thom, Neil Poulter, Jane Field, Anushka Patel, Dorairaj Prabhakaran, Alice Stanton, Diederick E Grobbee, Michiel L Bots, K Srinath Reddy, Raghu Cidambi, Severine Bompoint, Laurent Billot, Anthony Rodgers, UMPIRE Collaborative Group
Publication date
2013/9/4
Journal
Jama
Volume
310
Issue
9
Pages
918-929
Publisher
American Medical Association
Description
Importance
Most patients with cardiovascular disease (CVD) do not take recommended medications long-term. The use of fixed-dose combinations (FDCs) improves adherence in several clinical areas. Previous trials of cardiovascular FDCs have assessed short-term effects compared with placebo or no treatment.
Objective
To assess whether FDC delivery of aspirin, statin, and 2 blood pressure–lowering agents vs usual care improves long-term adherence to indicated therapy and 2 major CVD risk factors, systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C).
Design, Setting, and Participants
The UMPIRE trial, a randomized, open-label, blinded-end-point trial among 2004 participants with established CVD or at risk of CVD enrolled July 2010–July 2011 in India and Europe. The trial follow-up concluded in July 2012.
Interventions
Participants were randomly assigned (1:1) to an FDC-based …
Scholar articles
S Thom, N Poulter, J Field, A Patel, D Prabhakaran… - Jama, 2013