Authors
Alexander Makarov, Eduard Denisov, Alexander Kholomeev, Wilko Balschun, Oliver Lange, Kerstin Strupat, Stevan Horning
Publication date
2006/4/1
Journal
Analytical chemistry
Volume
78
Issue
7
Pages
2113-2120
Publisher
American Chemical Society
Description
Design and performance of a novel hybrid mass spectrometer is described. It couples a linear ion trap mass spectrometer to an orbitrap mass analyzer via an rf-only trapping quadrupole with a curved axis. The latter injects pulsed ion beams into a rapidly changing electric field in the orbitrap wherein they are trapped at high kinetic energies around an inner electrode. Image current detection is subsequently performed after a stable electrostatic field is achieved. Fourier transformation of the acquired transient allows wide mass range detection with high resolving power, mass accuracy, and dynamic range. The entire instrument operates in LC/MS mode (1 spectrum/s) with nominal mass resolving power of 60 000 and uses automatic gain control to provide high-accuracy mass measurements, within 2 ppm using internal standards and within 5 ppm with external calibration. The maximum resolving power exceeds 100 …
Total citations
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Scholar articles
A Makarov, E Denisov, A Kholomeev, W Balschun… - Analytical chemistry, 2006