Authors
Pauline Favre, Melissa Pauling, Jacques Stout, Franz Hozer, Samuel Sarrazin, Christoph Abé, Martin Alda, Clara Alloza, Silvia Alonso-Lana, Ole A Andreassen, Bernhard T Baune, Francesco Benedetti, Geraldo F Busatto, Erick J Canales-Rodriguez, Xavier Caseras, Tiffany Moukbel Chaim-Avancini, Christopher RK Ching, Udo Dannlowski, Michael Deppe, Lisa T Eyler, Mar Fatjo-Vilas, Sonya F Foley, Dominik Grotegerd, Tomas Hajek, Unn K Haukvik, Fleur M Howells, Neda Jahanshad, Harald Kugel, Trine V Lagerberg, Stephen M Lawrie, Julia O Linke, Andrew McIntosh, Elisa MT Melloni, Philip B Mitchell, Mircea Polosan, Edith Pomarol-Clotet, Jonathan Repple, Gloria Roberts, Annerine Roos, Pedro GP Rosa, Raymond Salvador, Salvador Sarró, Peter R Schofield, Mauricio H Serpa, Kang Sim, Dan J Stein, Jess E Sussmann, Henk S Temmingh, Paul M Thompson, Norma Verdolini, Eduard Vieta, Michele Wessa, Heather C Whalley, Marcus V Zanetti, Marion Leboyer, Jean-François Mangin, Chantal Henry, Edouard Duchesnay, Josselin Houenou, ENIGMA Bipolar Disorder Working Group
Publication date
2019/12
Journal
Neuropsychopharmacology
Volume
44
Issue
13
Pages
2285-2293
Publisher
Springer International Publishing
Description
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with …
Scholar articles
P Favre, M Pauling, J Stout, F Hozer, S Sarrazin, C Abé… - Neuropsychopharmacology, 2019