Authors
Samuel Sarrazin, Cyril Poupon, Julia Linke, Michèle Wessa, Mary Phillips, Marine Delavest, Amelia Versace, Jorge Almeida, Pamela Guevara, Delphine Duclap, Edouard Duchesnay, Jean-François Mangin, Katia Le Dudal, Claire Daban, Nora Hamdani, Marc-Antoine D’Albis, Marion Leboyer, Josselin Houenou
Publication date
2014/4/1
Journal
JAMA psychiatry
Volume
71
Issue
4
Pages
388-396
Publisher
American Medical Association
Description
Importance
Tractography studies investigating white matter (WM) abnormalities in patients with bipolar disorder have yielded heterogeneous results owing to small sample sizes. The small size limits their generalizability, a critical issue for neuroimaging studies of biomarkers of bipolar I disorder (BPI).
Objectives
To study WM abnormalities using whole-brain tractography in a large international multicenter sample of BPI patients and to compare these alterations between patients with or without a history of psychotic features during mood episodes.
Design, Setting, and Participants
A cross-sectional, multicenter, international, Q-ball imaging tractography study comparing 118 BPI patients and 86 healthy control individuals. In addition, among the patient group, we compared those with and without a history of psychotic features. University hospitals in France, Germany, and the United States contributed participants …
Scholar articles
S Sarrazin, C Poupon, J Linke, M Wessa, M Phillips… - JAMA psychiatry, 2014