Authors
Cameron C Grant, Alistair W Stewart, Robert Scragg, Tania Milne, Judy Rowden, Alec Ekeroma, Clare Wall, Edwin A Mitchell, Sue Crengle, Adrian Trenholme, Julian Crane, Carlos A Camargo Jr
Publication date
2014/1/1
Journal
Pediatrics
Volume
133
Issue
1
Pages
e143-e153
Publisher
American Academy of Pediatrics
Description
OBJECTIVE
To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥20 ng/mL during infancy.
METHODS
A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks’ gestation to birth, and then their infants, from birth to age 6 months, were randomly assigned to 1 of 3 mother/infant groups: placebo/placebo, vitamin D3 1000/400 IU, or vitamin D3 2000/800 IU. Serum 25(OH)D and calcium concentrations were measured at enrollment, 36 weeks’ gestation, in cord blood, and in infants at 2, 4, and 6 months of age.
RESULTS
Two-hundred-and-sixty pregnant women were randomized. At enrollment, the proportions with serum 25(OH)D ≥20 ng/mL for placebo, lower-dose, and higher-dose groups were 54%, 64%, and 55%, respectively. The proportion with 25(OH)D …
Scholar articles
CC Grant, AW Stewart, R Scragg, T Milne, J Rowden… - Pediatrics, 2014