Authors
Vanessa Selak, C Raina Elley, Chris Bullen, Sue Crengle, Angela Wadham, Natasha Rafter, Varsha Parag, Matire Harwood, Robert N Doughty, Bruce Arroll, Richard J Milne, Dale Bramley, Linda Bryant, Rod Jackson, Anthony Rodgers
Publication date
2014/5/27
Journal
Bmj
Volume
348
Publisher
British Medical Journal Publishing Group
Description
Objective To evaluate whether provision of fixed dose combination treatment improves adherence and risk factor control compared with usual care of patients at high risk of cardiovascular disease in primary care.
Design Open label randomised control trial: IMPACT (IMProving Adherence using Combination Therapy).
Setting 54 general practices in the Auckland and Waikato regions of New Zealand, July 2010 to August 2013.
Participants 513 adults (including 257 indigenous Māori) at high risk of cardiovascular disease (established cardiovascular disease or five year risk ≥15%) who were recommended for treatment with antiplatelet, statin, and two or more blood pressure lowering drugs. 497 (97%) completed 12 months’ follow-up.
Interventions Participants were randomised to continued usual care or to fixed dose combination treatment (with two versions available: aspirin 75 mg, simvastatin 40 mg, and lisinopril 10 …
Scholar articles
V Selak, CR Elley, C Bullen, S Crengle, A Wadham… - Bmj, 2014