Authors
Ruth Webster, Anushka Patel, Vanessa Selak, Laurent Billot, Michiel L Bots, Alex Brown, Chris Bullen, Alan Cass, Sue Crengle, C Raina Elley, Diederick E Grobbee, Bruce Neal, David Peiris, Neil Poulter, Dorairaj Prabhakaran, Natasha Rafter, Alice Stanton, Sandrine Stepien, Simon Thom, Tim Usherwood, Angela Wadham, Anthony Rodgers, SPACE Collaboration
Publication date
2016/2/15
Journal
International journal of cardiology
Volume
205
Pages
147-156
Publisher
Elsevier
Description
Aims
To conduct a prospective, individual participant data (IPD) meta-analysis of randomised controlled trials comparing a polypill-based approach with usual care in high risk individuals.
Methods and results
Three trials comparing polypill-based care with usual care in individuals with CVD or high calculated cardiovascular risk contributed IPD. Primary outcomes were self-reported adherence to combination therapy (anti-platelet, statin and ≥ two blood pressure (BP) lowering agents), and difference in mean systolic BP (SBP) and LDL-cholesterol at 12 months. Analyses used random effects models. Among 3140 patients from Australia, England, India, Ireland, New Zealand and The Netherlands (75% male, mean age 62 years), median follow-up was 15 months. At baseline, 84%, 87% and 61% respectively were taking a statin, anti-platelet agent and at least two BP lowering agents. At 12 months, compared to usual …
Scholar articles
R Webster, A Patel, V Selak, L Billot, ML Bots, A Brown… - International journal of cardiology, 2016