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Automated multidisciplinary design of aircraft and other flight vehicles requires the optimization of complex performance objectives with respect to a number of design parameters and constraints. The effect of these independent design variables on the system performance criteria can be quantified in terms of sensitivity derivatives which must be calculated and propagated by the individual discipline simulation codes. Typical advanced CFD analysis codes do not provide such derivatives as part of a flow solution; these derivatives are very expensive to obtain by divided (finite) differences from perturbed solutions. It is shown here that sensitivity derivatives can be obtained accurately and efficiently by using the ADIFOR source translator for automatic differentiation. In particular, it is demonstrated that the 3D, thin-layer Navier-Stokes, multigrid flow solver called TLNS3D is amenable to automatic differentiation in the …