Authors
John W Hubbard, Nuggehally R Srinivas, Declan Quinn, Kamal K Midha
Publication date
1989/11
Journal
Journal of pharmaceutical sciences
Volume
78
Issue
11
Pages
944-947
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
It has been shown previously that immediate‐release dl‐threo‐methylphenidate (Ritalin) undergoes stereoselective disposition in human adults as well as in children with attention deficit‐hyperactivity disorder. Although the sustained‐release formulation of dl‐threo‐methylphenidate (Ritalin‐SR) has been demonstrated to be effective in sustaining the attention of the children with attention deficit‐hyperactivity disorder, there are no data on plasma levels of methylphenidate after administration of the sustained‐release formulation. The purpose of this present investigation was twofold: (1) to determine whether the levels of methylphenidate were sustained for over a time period of 8 h, and (2) to examine enantioselective aspects of the pharmacokinetics following the ingestion of the sustained‐release formulation. Six children with attention deficit‐hyperactivity disorder were given 20 mg of sustained‐release dl‐threo …
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