Authors
Annette WK Tso, Aimin Xu, Pak C Sham, Nelson MS Wat, Yu Wang, Carol HY Fong, Bernard MY Cheung, Edward D Janus, Karen SL Lam
Publication date
2007/10/1
Journal
Diabetes care
Volume
30
Issue
10
Pages
2667-2672
Publisher
American Diabetes Association
Description
OBJECTIVE— Adipocyte fatty acid–binding protein (A-FABP) is abundantly expressed in adipocytes and plays a role in glucose homeostasis in experimental animals. We have previously shown that circulating A-FABP levels are associated with the metabolic syndrome, which confers an increased risk of type 2 diabetes. Here we investigated whether serum A-FABP levels could predict the development of diabetes in a 10-year prospective study.
RESEARCH DESIGN AND METHODS— Baseline serum A-FABP levels were measured with an enzyme-linked immunosorbent assay in 544 nondiabetic subjects, recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort, who were followed prospectively to assess the development of type 2 diabetes. The role of A-FABP in predicting the development of type 2 diabetes over 10 years was investigated using Cox regression analysis …
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AWK Tso, A Xu, PC Sham, NMS Wat, Y Wang… - Diabetes care, 2007