Authors
Eric Tawagi, Kyle DW Vollett, Daniel A Szulc, J Paul Santerre, Hai‐Ling Margaret Cheng
Publication date
2023/10
Journal
Journal of Magnetic Resonance Imaging
Volume
58
Issue
4
Pages
1139-1150
Publisher
John Wiley & Sons, Inc.
Description
Background
A noninvasive method to track implanted biomaterials is desirable for real‐time monitoring of material interactions with host tissues and assessment of efficacy and safety.
Purpose
To explore quantitative in vivo tracking of polyurethane implants using a manganese porphyrin (MnP) contrast agent containing a covalent binding site for pairing to polymers.
Study Type
Prospective, longitudinal.
Animal Model
Rodent model of dorsal subcutaneous implants (10 female Sprague Dawley rats).
Field Strength/Sequence
A 3‐T; two‐dimensional (2D) T1‐weighted spin‐echo (SE), T2‐weighted turbo SE, three‐dimensional (3D) spoiled gradient‐echo T1 mapping with variable flip angles.
Assessment
A new MnP‐vinyl contrast agent to covalently label polyurethane hydrogels was synthesized and chemically characterized. Stability of binding was assessed in vitro. MRI was performed in vitro on unlabeled …
Total citations
Scholar articles
E Tawagi, KDW Vollett, DA Szulc, JP Santerre… - Journal of Magnetic Resonance Imaging, 2023