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To survey the recent literature from the late 1980s to recent years in order to assess the relationship between resin degradation, catalyzed by biological factors, and clinical failure outcomes such as marginal breakdown.

The literature shows that degradation occurs in many manufacturers’ products despite varied vinyl acrylate compositions. The authors examine salivary enzyme activity and their ability to degrade the polymeric matrix of resin composites and adhesives, as well as oral microorganisms that can promote demineralization of the tooth surface at the marginal interface. A survey of recent research relating matrix metalloproteinase (MMPs) to the degradation of the exposed collagen at the dentin adhesive interface is also discussed in the context of marginal breakdown.

The literature provides strong support that together, the above factors can breakdown the marginal interface and …