Authors
SJ Graham, GJ Stanisz, A Kecojevic, MJ Bronskill, RM Henkelman
Publication date
1999/12
Journal
Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine
Volume
42
Issue
6
Pages
1061-1071
Publisher
John Wiley & Sons, Inc.
Description
To characterize changes in the MR parameters of tissues due to thermal coagulation, a series of T1, T2, diffusion, and magnetization transfer measurements were performed on a variety of ex vivo tissues: murine slow twitch skeletal muscle, murine cardiac muscle, murine cerebral hemisphere, bovine white matter, murine liver tissue, bovine retroperitoneal adipose tissue, hen egg white, human prostate and human blood. Standardized heat treatments were performed for each tissue type, over the temperature range from 37°C to 90°C. For all tissues, changes in each MR measurement resulting from thermal coagulation were observed above a threshold temperature of approximately 60°C. These changes are explained based on biophysical knowledge of thermal damage mechanisms and the MR properties of normal tissues, and are particularly relevant for interpreting the changes in image contrast that are …
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SJ Graham, GJ Stanisz, A Kecojevic, MJ Bronskill… - Magnetic Resonance in Medicine: An Official Journal of …, 1999