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It has been proposed that genetic factors drive early onset atopic dermatitis (AD) while environmental exposures drive late onset AD. Mutations in filaggrin (FLG) increase the odds of AD, and single-nucleotide polymorphisms in thymic stromal lymphopoietin (TSLP) are linked to less persistent AD. Our aim was to examine the impact of FLG mutations and TSLP polymorphisms on the timing of AD onset. We performed a cross-sectional study using the Pediatric Eczema Elective Registry, a cohort of children with physician-confirmed diagnosis of AD. A total of 798 subjects were genotyped for 4 common FLG null mutations (R501X, 2282del4, R2447X, S3247X) and 770 subjects were genotyped for TSLP rs1898671. Age of AD onset was self-reported by the subject or caregiver. Logistic regression was performed to compare the odds of early onset AD (defined as≤ 2 years old) with respect to FLG and TSLP status under …