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Cutaneous infections are common in atopic dermatitis (AD) due to impaired skin barrier and immunologic dysfunction. Early-and late-onset pediatric AD are distinct phenotypes that vary in disease persistence and risk of other atopic comorbidities. However, whether infection risk varies by the timing of AD onset is unknown. Using population-based, electronic medical records data from the UK, we examined a cohort of children enrolled within the first year of life and who had a diagnosis of AD before age 18. Among 154,022, 30,970, and 4,788 children with early-(≤ 2 years old), mid-(3-7 years old), and late-onset (8-17 years old) AD, those with late-onset AD were 20-25% less likely to have molluscum (OR 0.74, 95% CI 0.68-0.80), varicella/herpes zoster (0.75, 0.70-0.79), impetigo (0.78, 0.72-0.83) and herpes simplex virus (0.81, 0.69-0.96), after adjusting for age, sex, duration of follow-up, and other atopy. They also …