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Atopic dermatitis (AD) is a relapsing inflammatory skin disease; filaggrin (FLG) variation has been consistently associated with its pathogenesis. Filaggrin-2 (FLG2) and trichohyalin-like-1 (TCHHL1) are members of the same protein family (S100 fused type proteins), are similar in structure to FLG, and may be involved in AD pathogenesis. We sought to evaluate the association between variation in FLG2, TCHHL1 and AD remission. We sequenced FLG2 and TCHHL1 in a longitudinal cohort of individuals with AD using targeted capture based massively parallel sequencing. The association between individual alleles and AD remission was evaluated with generalized estimating equations (GEE) for binary outcomes, assuming an exchangeable working correlation structure with empirical standard errors. The association between groups of alleles and AD remission was evaluated using a genetic algorithm …