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To address the research gap around persistence of atopic dermatitis (AD) into adulthood, we performed a longitudinal cohort study to 1) define patterns of AD disease control over time and 2) examine basic patient characteristics associated with each pattern. We used data on self-reported disease control and medication use from 5,798 children and young adults ages 2-26 years with physician-diagnosed AD. They were followed at 6-month intervals for up to 10 years in the Pediatric Elective Eczema Registry (PEER). We performed a latent class analysis using generalized linear latent and mixed models and found 2 distinct classes of individuals: 91% fell into a ‘persistently active’class, and 9% fell into a ‘resolving’class that was more likely to report better disease control with age. Patients in the persistently active class were more likely to be female (54% vs 44%) and non-white (59% vs 47%), less likely report family …