Authors
Timothy van Haaften, Roisin Byrne, Sebastien Bonnet, Gael Y Rochefort, John Akabutu, Manaf Bouchentouf, Gloria J Rey-Parra, Jacques Galipeau, Alois Haromy, Farah Eaton, Ming Chen, Kyoko Hashimoto, Doris Abley, Greg Korbutt, Stephen L Archer, Bernard Thébaud
Publication date
2009/12/1
Journal
American journal of respiratory and critical care medicine
Volume
180
Issue
11
Pages
1131-1142
Publisher
American Thoracic Society
Description
Rationale: Bronchopulmonary dysplasia (BPD) and emphysema are characterized by arrested alveolar development or loss of alveoli; both are significant global health problems and currently lack effective therapy. Bone marrow–derived mesenchymal stem cells (BMSCs) prevent adult lung injury, but their therapeutic potential in neonatal lung disease is unknown.
Objectives: We hypothesized that intratracheal delivery of BMSCs would prevent alveolar destruction in experimental BPD.
Methods: In vitro, BMSC differentiation and migration were assessed using co-culture assays and a modified Boyden chamber. In vivo, the therapeutic potential of BMSCs was assessed in a chronic hyperoxia-induced model of BPD in newborn rats.
Measurements and Main Results: In vitro, BMSCs developed immunophenotypic and ultrastructural characteristics of type II alveolar epithelial cells (AEC2) (surfactant protein C expression …
Total citations
Scholar articles
T van Haaften, R Byrne, S Bonnet, GY Rochefort… - American journal of respiratory and critical care …, 2009