Authors
Hongchao Pan, Richard Peto, Ana Maria Henao Restrepo, Marie-Pierre Preziosi, Vasee Sathiyamoorthy, Quarraisha Abdool Karim, Marissa Alejandria, César Hernàndez García, Marie-Paule Kieny, Reza Malekzadeh, Srinivas Murthy, K Srinath Reddy, Mirta Roses Periago, Pierre Abi Hanna, Akaki Abutidze, Florence Ader, Abdullah Al-Bader, Almonther Alhasawi, Emma Allum, Adhra Al Mawali, Athari Alotaibi, Carlos Alvarez-Moreno, Sheila Appadoo, Derk Arts, Abdullah Asiri, Pål Aukrust, Andreas Barratt-Due, Abebe Genetu Bayih, Helena Beaumont, Samir Bellani, Virginia Benassi, Balram Bhargava, Mattia Branca, Heike Cappel-Porter, Nery Cerrato, Fadima Cheick Haidara, Ting Soo Chow, Nadia Como, Joe Eustace, Tamar Gabunia, Patricia García, Sheela Godbole, Eduardo Gotuzzo, Laimonas Griskevicius, Rasha Hamra, Mariam Hassan, Mohamed Hassany, David Hutton, Irmansyah Irmansyah, Ligita Jancoriene, Faryal Khamis, Jana Kirwan, Suresh Kumar, Peter Lennon, Gustavo Lopardo, Patrick Lydon, Nicola Magrini, Suzana Manevska, Oriol Manuel, Sybil McGinty, Marco Medina, Maria Lucia Mesa Rubio, Maria Consuelo Miranda Montoya, Jeremy Nel, Estevao Nunes, Markus Perola, Antonio Portoles, Menaldi Rasmin, Aun Raza, Helen Rees, Paula Reges, Chris Rogers, Kolawole Salami, Marina Salvadori, Mamatha Sauermann, Narvina Sinani, Samba Sow, Jonathan AC Sterne, Milena Stevanovikj, Evelina Tacconelli, Fernando Manuel Tavares Maltez, Mekonnen Teferi, Kari Tikkinen, Sven Trelle, Tengiz Tsertsvadze, Hala Zaid, John-Arne Røttingen, Soumya Swaminathan, Michael Ryan, Nevila Gjermeni, Esmeralda Meta, Damian Aguila, Ignacio Alonso, Marcos Altamirano, María Alvarez, Rodrigo Alzola, Veronica Arce, Patricia Arribillaga, Rafael Avila, Juan Balbuena, Laura Barcelona, José Barletta, María Benedetti, Verónica Berdiñas, Julieta Burgui, Sabrina Caimi, Juan Carrillo, Juan Carrizo, Juan Castelli, Alexis Cazaux, Flavia Cervellino, Angelo Chalco, Viviana Chediack, Eleonora Cunto, Nicolàs D'Amico, Lautaro de Vedia, Carolina Delgado, Debora Di Pilla, Miguel Díaz, Pablo Díaz Aguiar, Cecilia Domínguez, Leonor Ellero, Javier Farina, José Fernàndez, Roxana Ferreyra, María Filippi, Carolina Fogar, Pablo Frare, Celeste Giudiche, Mariana Golikow, Maria Georgina Gomez, Laura Hermida, Mariano Hurtado, Mariela Jacobo, Martin Jaume, Diego Laplume, María Lescano, Nicolàs Lista, Flavia Loiacono, Ana Belen López, Marcelo Losso, Cecilia Luna, Sergio Lupo, Leonardo Marianelli, Anabella Martin, Florencia Masciottra, Analía Mykietiuk, Lorena Orellano, Valeria Pachioli, María José Padilla
Publication date
2022/5/21
Journal
The Lancet
Volume
399
Issue
10339
Pages
1941-1953
Publisher
Elsevier
Description
Background
The Solidarity trial among COVID-19 inpatients has previously reported interim mortality analyses for four repurposed antiviral drugs. Lopinavir, hydroxychloroquine, and interferon (IFN)-β1a were discontinued for futility but randomisation to remdesivir continued. Here, we report the final results of Solidarity and meta-analyses of mortality in all relevant trials to date.
Methods
Solidarity enrolled consenting adults (aged ≥18 years) recently hospitalised with, in the view of their doctor, definite COVID-19 and no contraindication to any of the study drugs, regardless of any other patient characteristics. Participants were randomly allocated, in equal proportions between the locally available options, to receive whichever of the four study drugs (lopinavir, hydroxychloroquine, IFN-β1a, or remdesivir) were locally available at that time or no study drug (controls). All patients also received the local standard of care. No …
Total citations
Scholar articles
H Pan, R Peto, AMH Restrepo, MP Preziosi… - The Lancet, 2022