Authors
Rufus Cartwright, Anna C Kirby, Kari AO Tikkinen, Altaf Mangera, Gans Thiagamoorthy, Prabhakar Rajan, Jori Pesonen, Chris Ambrose, Juan Gonzalez-Maffe, Phillip Bennett, Tom Palmer, Andrew Walley, Marjo-Riitta Järvelin, Chris Chapple, Vik Khullar
Publication date
2015/2/1
Source
American journal of obstetrics and gynecology
Volume
212
Issue
2
Pages
199. e1-199. e24
Publisher
Mosby
Description
Objective
Family studies and twin studies demonstrate that lower urinary tract symptoms and pelvic organ prolapse are heritable. This review aimed to identify genetic polymorphisms tested for an association with lower urinary tract symptoms or prolapse, and to assess the strength, consistency, and risk of bias among reported associations.
Study Design
PubMed and HuGE Navigator were searched up to May 1, 2014, using a combination of genetic and phenotype key words, including “nocturia,” “incontinence,” “overactive bladder,” “prolapse,” and “enuresis.” Major genetics, urology, and gynecology conference abstracts were searched from 2005 through 2013. We screened 889 abstracts, and retrieved 78 full texts. In all, 27 published and 7 unpublished studies provided data on polymorphisms in or near 32 different genes. Fixed and random effects metaanalyses were conducted using codominant models of …
Scholar articles
R Cartwright, AC Kirby, KAO Tikkinen, A Mangera… - American journal of obstetrics and gynecology, 2015