Authors
Karoliina Tainio, Antonios Athanasiou, Kari AO Tikkinen, Riikka Aaltonen, Jovita Cárdenas, Sivan Glazer-Livson, Maija Jakobsson, Kirsi Joronen, Mari Kiviharju, Karolina Louvanto, Sanna Oksjoki, Riikka Tähtinen, Seppo Virtanen, Pekka Nieminen, Maria Kyrgiou, Ilkka Kalliala
Publication date
2018/2/27
Source
bmj
Volume
360
Publisher
British Medical Journal Publishing Group
Description
Objective
To estimate the regression, persistence, and progression of untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions managed conservatively as well as compliance with follow-up protocols.
Design
Systematic review and meta-analysis.
Data sources
Medline, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) from 1 January 1973 to 20 August 2016.
Eligibility criteria
Studies reporting on outcomes of histologically confirmed CIN2 in non-pregnant women, managed conservatively for three or more months.
Data synthesis
Two reviewers extracted data and assessed risk of bias. Random effects model was used to calculate pooled proportions for each outcome, and heterogeneity was assessed using I2 statistics.
Main outcome measures
Rates of regression, persistence, or progression of CIN2 and default rates at different follow-up time points (3, 6, 12, 24, 36, and 60 …
Scholar articles
K Tainio, A Athanasiou, KAO Tikkinen, R Aaltonen… - bmj, 2018