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Deposits of phosphorylated tau protein and convergence of pathology in the hippocampus are the hallmarks of neurodegenerative tauopathies. Thus we aimed to evaluate whether regional and cellular vulnerability patterns in the hippocampus distinguish tauopathies or are influenced by their concomitant presence. We created a heat map of phospho-tau (AT8) immunoreactivity patterns in 24 hippocampal subregions/layers in individuals with Alzheimer's disease (AD)-related neurofibrillary degeneration (n= 40), Pick's disease (n= 8), progressive supranuclear palsy (n= 7), corticobasal degeneration (n= 6), argyrophilic grain disease (AGD, n= 18), globular glial tauopathy (n= 5), and tau-astrogliopathy of the elderly (n= 10). AT8 immunoreactivity patterns were compared by mathematical analysis. Our study reveals disease-specific hot spots and regional selective vulnerability for …