Authors
Ethan J Anderson, Jimmy T Efird, Stephen W Davies, Wesley T O'Neal, Timothy M Darden, Kathleen A Thayne, Lalage A Katunga, Linda C Kindell, T Bruce Ferguson, Curtis A Anderson, W Randolph Chitwood, Theodore C Koutlas, J Mark Williams, Evelio Rodriguez, Alan P Kypson
Publication date
2014/2/26
Journal
Journal of the American Heart Association
Volume
3
Issue
1
Pages
e000713
Description
Background
Onset of postoperative atrial fibrillation (POAF) is a common and costly complication of heart surgery despite major improvements in surgical technique and quality of patient care. The etiology of POAF, and the ability of clinicians to identify and therapeutically target high‐risk patients, remains elusive.
Methods and Results
Myocardial tissue dissected from right atrial appendage (RAA) was obtained from 244 patients undergoing cardiac surgery. Reactive oxygen species (ROS) generation from multiple sources was assessed in this tissue, along with total glutathione (GSHt) and its related enzymes GSH‐peroxidase (GPx) and GSH‐reductase (GR). Monoamine oxidase (MAO) and NADPH oxidase were observed to generate ROS at rates 10‐fold greater than intact, coupled mitochondria. POAF risk was significantly associated with MAO activity (Quartile 1 [Q1]: adjusted relative risk [ARR]=1.0; Q2: ARR=1.8 …
Scholar articles
EJ Anderson, JT Efird, SW Davies, WT O'Neal… - Journal of the American Heart Association, 2014