Authors
Yunqi Li, Melissa A Richard, Linda Kachuri, Yao Yu, Ching-Ju Ruu Hsu, Tracie C Rosser, Elizabeth J Leslie, Meenakshi Devidas, Elizabeth A Raetz, Mignon L Loh, Stephen P Hunger, Neetha Paul Eduthan, Matthew D Galbraith, Joaquin Espinosa, Jun J Yang, Stephanie L Sherman, Chad D Huff, Karen R Rabin, Philip J Lupo, Adam J de Smith
Publication date
2023/11/28
Journal
Blood
Volume
142
Pages
4198
Publisher
Content Repository Only!
Description
Introduction: The risk of developing acute lymphoblastic leukemia (ALL) is up to 30-fold higher in children with Down syndrome (DS). While trisomy 21 increases the risk of leukemia, only ~1% of children with DS develop ALL (DS-ALL), suggesting that additional modifying risk factors exist. A recent study in individuals without DS revealed that a genetic propensity for increased lymphocyte production was associated with an increased risk of childhood ALL. Additionally, a previous genome-wide association study (GWAS) of DS-ALL identified associations in genes involved in lymphoid development. Here, we investigated whether genetic variation in lymphocyte-related traits is associated with DS-ALL risk, with the hypothesis that a genetic predisposition for lymphocyte overproduction is associated with an increased risk of DS-ALL.
Methods: We performed Mendelian randomization (MR) analyses to investigate the …
Scholar articles
Y Li, MA Richard, L Kachuri, Y Yu, CJR Hsu, TC Rosser… - Blood, 2023