Authors
Kathryn G Roberts, Yongjin Li, Debbie Payne-Turner, Richard C Harvey, Yung-Li Yang, Deqing Pei, Kelly McCastlain, Li Ding, Charles Lu, Guangchun Song, Jing Ma, Jared Becksfort, Michael Rusch, Shann-Ching Chen, John Easton, Jinjun Cheng, Kristy Boggs, Natalia Santiago-Morales, Ilaria Iacobucci, Robert S Fulton, Ji Wen, Marcus Valentine, Cheng Cheng, Steven W Paugh, Meenakshi Devidas, I-Ming Chen, Shalini Reshmi, Amy Smith, Erin Hedlund, Pankaj Gupta, Panduka Nagahawatte, Gang Wu, Xiang Chen, Donald Yergeau, Bhavin Vadodaria, Heather Mulder, Naomi J Winick, Eric C Larsen, William L Carroll, Nyla A Heerema, Andrew J Carroll, Guy Grayson, Sarah K Tasian, Andrew S Moore, Frank Keller, Melissa Frei-Jones, James A Whitlock, Elizabeth A Raetz, Deborah L White, Timothy P Hughes, Jaime M Guidry Auvil, Malcolm A Smith, Guido Marcucci, Clara D Bloomfield, Krzysztof Mrózek, Jessica Kohlschmidt, Wendy Stock, Steven M Kornblau, Marina Konopleva, Elisabeth Paietta, Ching-Hon Pui, Sima Jeha, Mary V Relling, William E Evans, Daniela S Gerhard, Julie M Gastier-Foster, Elaine Mardis, Richard K Wilson, Mignon L Loh, James R Downing, Stephen P Hunger, Cheryl L Willman, Jinghui Zhang, Charles G Mullighan
Publication date
2014/9/11
Journal
New England journal of medicine
Volume
371
Issue
11
Pages
1005-1015
Publisher
Massachusetts Medical Society
Description
Background
Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.
Methods
We performed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 154 patients with Ph-like ALL. We examined the functional effects of fusion proteins and the efficacy of tyrosine kinase inhibitors in mouse pre-B cells and xenografts of human Ph-like ALL.
Results
Ph-like ALL increased in frequency from 10% among children with standard-risk ALL to 27% among young adults with ALL and was associated with a poor outcome. Kinase-activating …
Total citations
Scholar articles
KG Roberts, Y Li, D Payne-Turner, RC Harvey… - New England journal of medicine, 2014