Authors
Stephen P Hunger, Xiaomin Lu, Meenakshi Devidas, Bruce M Camitta, Paul S Gaynon, Naomi J Winick, Gregory H Reaman, William L Carroll
Publication date
2012/5/10
Journal
Journal of clinical oncology
Volume
30
Issue
14
Pages
1663-1669
Publisher
American Society of Clinical Oncology
Description
Purpose
To examine population-based improvements in survival and the impact of clinical covariates on outcome among children and adolescents with acute lymphoblastic leukemia (ALL) enrolled onto Children's Oncology Group (COG) clinical trials between 1990 and 2005.
Patients and Methods
In total, 21,626 persons age 0 to 22 years were enrolled onto COG ALL clinical trials from 1990 to 2005, representing 55.8% of ALL cases estimated to occur among US persons younger than age 20 years during this period. This period was divided into three eras (1990-1994, 1995-1999, and 2000-2005) that included similar patient numbers to examine changes in 5- and 10-year survival over time and the relationship of those changes in survival to clinical covariates, with additional analyses of cause of death.
Results
Five-year survival rates increased from 83.7% in 1990-1994 to 90.4% in 2000-2005 (P < .001 …
Total citations
Scholar articles
SP Hunger, X Lu, M Devidas, BM Camitta, PS Gaynon… - Journal of clinical oncology, 2012