Authors
Richard C Harvey, Charles G Mullighan, I-Ming Chen, Walker Wharton, Fady M Mikhail, Andrew J Carroll, Huining Kang, Wei Liu, Kevin K Dobbin, Malcolm A Smith, William L Carroll, Meenakshi Devidas, W Paul Bowman, Bruce M Camitta, Gregory H Reaman, Stephen P Hunger, James R Downing, Cheryl L Willman
Publication date
2010/7/1
Journal
Blood, The Journal of the American Society of Hematology
Volume
115
Issue
26
Pages
5312-5321
Publisher
American Society of Hematology
Description
Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia revealed 29 of 207 cases (14%) with markedly elevated expression of CRLF2 (cytokine receptor-like factor 2). Each of the 29 cases harbored a genomic rearrangement of CRLF2: 18 of 29 (62%) had a translocation of the immunoglobulin heavy chain gene IGH@ on 14q32 to CRLF2 in the pseudoautosomal region 1 of Xp22.3/Yp11.3, whereas 10 (34%) cases had a 320-kb interstitial deletion centromeric of CRLF2, resulting in a P2RY8-CRLF2 fusion. One case had both IGH@-CRLF2 and P2RY8-CRLF2, and another had a novel CRLF2 rearrangement. Only 2 of 29 cases were Down syndrome. CRLF2 rearrangements were significantly associated with activating mutations of JAK1 or JAK2, deletion or mutation of IKZF1, and Hispanic/Latino ethnicity (Fisher exact test, P < .001 for each). Within …
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Scholar articles
RC Harvey, CG Mullighan, IM Chen, W Wharton… - Blood, The Journal of the American Society of …, 2010