Authors
Melissa A Richard, Meenakshi Devidas, Wenjian Yang, John P Woodhouse, Vilmarie Rodriguez, Johann K Hitzler, Reuven J Schore, Anne L Angiolillo, Michael J Burke, Wanda L Salzer, Elizabeth A Raetz, Mignon L Loh, Stephen P Hunger, Jun J Yang, Philip J Lupo, Karen R Rabin
Publication date
2022/6/15
Journal
Cancer Research
Volume
82
Issue
12_Supplement
Pages
2002-2002
Publisher
The American Association for Cancer Research
Description
Background: Children with Down syndrome (DS) have an increased risk of acute lymphoblastic leukemia (ALL) and are more likely to experience morbidity and mortality from infectious toxicities during treatment compared to those without DS. We sought to characterize genetic risk factors for sepsis among individuals with DS-ALL.
Methods: We performed a germline genome-wide association (GWAS) study for sepsis among 264 subjects with DS-ALL treated on Children’s Oncology Group (COG) protocols AALL0932 (N=181) and AALL1131 (N=83), for newly-diagnosed standard risk and high risk B-ALL, respectively. Sepsis was defined using Common Terminology Criteria for Adverse Events (v4.0), with a microbiologically confirmed grade 4 or 5 sepsis event reported during any phase of treatment to define the case and comparison groups. Germline genotyping on the Affymetrix SNP 6.0 or Illumina Omni 2.5Exome …
Scholar articles
MA Richard, M Devidas, W Yang, JP Woodhouse… - Cancer Research, 2022