Authors
Sandra Luna‐Fineman, Mauricio Castellanos, Monika L Metzger, L Fulgencio Baez, Armando Peña Hernandez, Miguel Bonilla, Soad Fuentes‐Alabi, Rosa Nieves, Jessica Blanco, Emanuela Rossi, Meenakshi Devidas, Yichen Chen, Magda Arreola, Pedro A de Alarcon
Publication date
2024/2
Journal
Pediatric Blood & Cancer
Volume
71
Issue
2
Pages
e30792
Description
Background/objectives
High‐risk Hodgkin lymphoma (HRHL) in children is curable with combined modality therapy. The Association of Pediatric Hematology‐Oncology of Central America (AHOPCA) is a consortium of cancer centers from Central America. In 2004, AHOPCA implemented a guideline with a short course of chemotherapy (mStanfordV), strict diagnostics, and radiation guidelines, aimed at reducing abandonment and improving outcomes.
Methods
Newly diagnosed children less than 18 years of age with high‐risk HL (Ann Arbor stages: IIB, IIIB, IV) from AHOPCA centers were staged with chest radiography and ultrasound or computed tomography. Therapy was a modified Stanford V (mStanfordV), substituting cyclophosphamide for mechlorethamine and involved field radiation.
Results
Of 219 patients with HRHL, 181 patients were eligible and evaluable; 146 (81%) were boys, 22% being less than 6 …
Total citations
20241
Scholar articles
S Luna‐Fineman, M Castellanos, ML Metzger, LF Baez… - Pediatric Blood & Cancer, 2024