Authors
Rashmi Tripathi, Sunil Patel, Vandana Kumari, Pavan Chakraborty, Pritish Kumar Varadwaj
Publication date
2016/12
Journal
Network Modeling Analysis in Health Informatics and Bioinformatics
Volume
5
Pages
1-14
Publisher
Springer Vienna
Description
The significant role of long non-coding RNAs (lncRNAs) in various cellular functions, such as gene imprinting, immune response, embryonic pluripotency, tumorogenesis, and genetic regulations, has been widely studied and reported in recent years. Several experimental and computational methods involving genome-wide search and screenings of ncRNAs are being proposed utilizing sequence features-length, occurrence, and composition of bases with various limitations. The proposed classifier, Deep Neural Network (DNN) is fast and an accurate alternative for the identification of lncRNAs as compared to other existing classifiers. The information content stored in k-mer pattern has been used as a sole feature for the DNN classifier using manually annotated training datasets from LNCipedia and RefSeq database, obtaining accuracy of 98.07 %, sensitivity of 98.98 %, and specificity of 97.19 …
Total citations
2016201720182019202020212022202320241611111915661
Scholar articles
R Tripathi, S Patel, V Kumari, P Chakraborty… - Network Modeling Analysis in Health Informatics and …, 2016