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Another troubling issue arose where a claim was drafted disclosing only a correlation between two things, often the presence of an isoform or mutation and some multigenic disorder or a disorder having a genetic component. In some cases, the patent holder did not describe how the correlation was used to predict the disease. One such patent claims a method of detecting whether a subject is at increased risk of developing late-onset Alzheimer’s disease, comprising directly or indirectly detecting the presence or absence of a particular protein isoform. The claim does not account for other factors that relate to a person’s developing Alzheimer’s disease and does not indicate the specific relation between the presence of the isoform and the increased risk, but merely provides that there is a correlation. In fact, even where a patient does not have the isoform, he or she could still develop the disease, and those with the …