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We present performance characterization of a bio-potential recording system with an asynchronous readout architecture. The signal processing chain consists of a low-noise bio-potential amplifier, spike detection circuitry, and an address event representation (AER) communication protocol. The system was fabricated in a 0.5 pm CMOS technology. Each stage of the recording system was tested individually, and the systems' detection specificity and sensitivity were evaluated. For input spike amplitudes of 560 μV, a detection rate of 81 % was obtained with a false positive rate of 7 %.