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This book describes, in detail, statistical methods used in the analysis of population genetic data of a discrete (enumeration) nature, such as genotype frequencies. It is not concerned with the analysis of continuously variable traits. It is the author's hope that the book will bridge the gap between Elandt-Johnson's Probability Models and Statistical Methods in Genetics, published 20 years ago, and the range of techniques currently encountered in the scientific literature. The introductory chapter deals with the nature of genetic data and sampling, notation and terminology, and discusses the historical controversy over the goodness of fit of Mendel's experimental data to theoretical expectation. There follow chapters on the following: estimating frequencies (multinomial genotypic counts, likelihood estimation, etc); disequilibrium (Hardy-Weinberg, linkage); measures of gene diversity and heterozygosity; population …