Authors
Krystal J Thomas-White, Evann E Hilt, Cynthia Fok, Meghan M Pearce, Elizabeth R Mueller, Stephanie Kliethermes, Kristin Jacobs, Michael J Zilliox, Cynthia Brincat, Travis K Price, Gina Kuffel, Paul Schreckenberger, Xiaowu Gai, Linda Brubaker, Alan J Wolfe
Publication date
2016/5
Journal
International urogynecology journal
Volume
27
Pages
723-733
Publisher
Springer London
Description
Introduction and hypothesis
Many adult women have resident urinary bacteria (urinary microbiome/microbiota). In adult women affected by urinary urgency incontinence (UUI), the etiologic and/or therapeutic role of the urinary microbiome/microbiota remains unknown. We hypothesized that microbiome/microbiota characteristics would relate to clinically relevant treatment response to UUI medication per os.
Methods
Adult women initiating medication treatment orally for UUI and a comparator group of unaffected women were recruited in a tertiary care health-care system. All participants provided baseline clinical data and urine samples. Women with UUI were given 5 mg solifenacin, with potential dose escalation to 10 mg for inadequate UUI symptom control at 4 weeks. Additional data and urine samples were collected from women with UUI at 4 and 12 …
Scholar articles
KJ Thomas-White, EE Hilt, C Fok, MM Pearce… - International urogynecology journal, 2016