Authors
D Bell, A Berchuck, M Birrer, J Chien, DW Cramer, F Dao, R Dhir, P DiSaia, H Gabra, P Glenn, AK Godwin, J Gross, L Hartmann, M Huang, DG Huntsman, M Iacocca, M Imielinski, S Kalloger, BY Karlan, DA Levine, GB Mills, C Morrison, D Mutch, N Olvera, S Orsulic, K Park, N Petrelli, B Rabeno, JS Rader, BI Sikic, K Smith-McCune, AK Sood, D Bowtell, R Penny, JR Testa, K Chang, HH Dinh, JA Drummond, G Fowler, P Gunaratne, AC Hawes, CL Kovar, LR Lewis, MB Morgan, IF Newsham, J Santibanez, JG Reid, LR Trevino, Y-Q Wu, M Wang, DM Muzny, DA Wheeler, RA Gibbs, G Getz, MS Lawrence, K Cibulskis, AY Sivachenko, C Sougnez, D Voet, J Wilkinson, T Bloom, K Ardlie, T Fennell, J Baldwin, S Gabriel, ES Lander, L Ding, RS Fulton, DC Koboldt, MD McLellan, T Wylie, J Walker, M O’Laughlin, DJ Dooling, L Fulton, R Abbott, ND Dees, Q Zhang, C Kandoth, M Wendl, W Schierding, D Shen, CC Harris, H Schmidt, J Kalicki, KD Delehaunty, CC Fronick, R Demeter, L Cook, JW Wallis, L Lin, VJ Magrini, JS Hodges, JM Eldred, SM Smith, CS Pohl, F Vandin, BJ Raphael, GM Weinstock, ER Mardis, RK Wilson, M Meyerson, W Winckler, RGW Verhaak, SL Carter, CH Mermel, G Saksena, H Nguyen, RC Onofrio, D Hubbard, S Gupta, A Crenshaw, AH Ramos, L Chin, A Protopopov, Zhang Juinhua, TM Kim, I Perna, Y Xiao, H Zhang, G Ren, N Sathiamoorthy, RW Park, E Lee, PJ Park, R Kucherlapati, DM Absher, L Waite, G Sherlock, JD Brooks, JZ Li, J Xu, RM Myers, PW Laird, L Cope, JG Herman, H Shen, DJ Weisenberger, H Noushmehr, F Pan, T Triche Jr, BP Berman, DJ Van Den Berg, J Buckley, SB Baylin, PT Spellman, E Purdom, P Neuvial, H Bengtsson, LR Jakkula
Publication date
2011/6/1
Publisher
Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Description
The Cancer Genome Atlas (TCGA) project has analyzed mRNA expression, miRNA expression, promoter methylation, and DNA copy number in 489 high-grade serous ovarian adenocarcinomas (HGS-OvCa) and the DNA sequences of exons from coding genes in 316 of these tumors. These results show that HGS-OvCa is characterized by TP53 mutations in almost all tumors (96%); low prevalence but statistically recurrent somatic mutations in 9 additional genes including NF1, BRCA1, BRCA2, RB1, and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Analyses delineated four ovarian cancer transcriptional subtypes, three miRNA subtypes, four promoter methylation subtypes, a transcriptional signature associated with survival duration and shed new light on the impact on survival of tumors with BRCA1/2 and CCNE1 aberrations. Pathway …
Total citations
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Scholar articles
Cancer Genome Atlas Research Network (Participants … - Nature, 2011