Authors
Salvatore Mascia, Patrick L Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I Barton, Richard D Braatz, Charles L Cooney, James MB Evans, Timothy F Jamison, Klavs F Jensen, Allan S Myerson, Bernhardt L Trout
Publication date
2013/11/18
Journal
Angewandte Chemie
Volume
125
Issue
47
Pages
12585-12589
Publisher
WILEY‐VCH Verlag
Description
For the past decade, the pharmaceutical industry has been under pressure to improve efficiency, as rising costs outpaced the development of new pharmaceuticals.[1] A growing interest in green processes also highlights areas for possible improvements in pharmaceutical synthesis and manufacturing, where environmental impacts have been higher than for other industries.[2] Continuous manufacturing has attracted the attention of industry and academia alike by promising lower costs, greater reliability and safety, better sustainability, and novel pathways that are not otherwise accessible.[3] Recent studies have demonstrated that economic savings can be realized for certain cases by transforming a batch production into a continuous process.[4] With existing batchbased manufacturing methods, it can take up to 12 months between the start of the first synthetic step and market release of finished tablets,[5] which …
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