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A crucial factor in the development of sustainable crystallization processes is the use of biobased solvents, which, in turn, necessitates a comprehensive understanding of the solubility profiles of solid compounds in biobased solvents. The solubility of timolol maleate (TIM), used to treat glaucoma, was measured in commercial biobased solvents at temperatures ranging from 278.15 to 333.15 K using the polythermal method. Its solubility was determined in eight neat biobased solvents (acetone, 1-butanol, Cyrene, dimethyl isosorbide (DMI), ethanol, 2-methyltetrahydrofuran (2-MeTHF), 2-propanol, and water) and three binary solvent mixtures (ethanol + 2-propanol, ethanol + 2-MeTHF, and ethanol + DMI). It was demonstrated that the solubility of TIM increases with temperature in the pure solvents and solvent mixtures. Furthermore, the solubility of TIM decreases in ethanol with increasing 2-propanol, 2-MeTHF, or …