Authors
Giovanni Aprile, Ajinkya V Pandit, Jody Albertazzi, Ayse Eren, Gerard Capellades, Alpana A Thorat, Janaka C Gamekkanda, Thomas Vetter, Tommy Skovby, Gürkan Sin, Hao Wu, Kim Dam-Johansen, Allan S Myerson
Publication date
2023/10/2
Journal
Crystal Growth & Design
Volume
23
Issue
11
Pages
8052-8064
Publisher
American Chemical Society
Description
Continuous crystallization plays a pivotal role in the transition to continuous manufacturing that the pharmaceutical industry is currently undertaking. Alas, the development of a continuous crystallization process using data from continuous operation is prohibitively material-intensive. Given the state of control nature of the continuous formalism, experimental design spaces entail several experiments, in which up to ten residence times are required to assess an experimental condition at steady state. Furthermore, transferring batch kinetics determined from batch experiments to a continuous crystallizer, despite being common practice, adds undesirable uncertainty to the development endeavors due to equipment-dependent mass and heat transfer. In this work, we present a novel configuration of a tubular crystallizer, capable of characterizing a system with a few experiments, curbing the reactor footprint, and abating …
Total citations
Scholar articles
G Aprile, AV Pandit, J Albertazzi, A Eren, G Capellades… - Crystal Growth & Design, 2023