Authors
Ayse Eren, Jad Abou Ali, Wenchuan Ma, Marcellus Guedes Fernandes de Moraes, Dulashani Ruwanthika Ranasinghe Weerakkodige, Allan S Myerson
Publication date
2024/3/5
Journal
Crystal Growth & Design
Volume
24
Issue
6
Pages
2452-2461
Publisher
American Chemical Society
Description
The role of volume on the nucleation induction time and polymorphic outcome was investigated for 5-methyl-2-[(2-nitrophenyl) amino]-3-thiophenecarbonitrile (ROY) and sulfathiazole (SLFTZ) in a range of organic solvents. Generally, the results showed the expected trend of longer induction times for smaller volumes with consistent formation of one polymorph; however, in two cases (ROY–methanol and SLFTZ–methanol), an opposite trend was found with the induction time shortening with a smaller volume and a different polymorph nucleating.
Total citations
20241
Scholar articles
A Eren, JA Ali, W Ma, MGF de Moraes… - Crystal Growth & Design, 2024