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The development of website based blended learning is aimed to promote change in the acceleration of learning process in higher education which is not bound by space and time, thus will directly improve the quality of learning process in the Study Program of Biology Education of University of Samudra. Utilization of information and communication technology in the development of website based blended learningin higher education combines face to faceand online. Research is functioned as learning mediation between lecturers and students of Study Program of Biology Education of University of Samudra. Research and Development was performed through the model of 4D with stages consisted of Define, Design, Developmentand Disseminatewhich were modified in accordance with the needof researcher. Subjects of experiment were students, lecturers, as well as information and communication technology …