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We develop methods for analysing the ‘interaction’ or dependence between points in a spatial point pattern, when the pattern is spatially inhomogeneous. Completely non‐parametric study of interactions is possible using an analogue of the K‐function. Alternatively one may assume a semi‐parametric model in which a (parametrically specified) homogeneous Markov point process is subjected to (non‐parametric) inhomogeneous independent thinning. The effectiveness of these approaches is tested on datasets representing the positions of trees in forests.