Authors
Lik Chuan Lee, Martin Genet, Gabriel Acevedo-Bolton, Karen Ordovas, Julius M Guccione, Ellen Kuhl
Publication date
2015/4
Journal
Biomechanics and modeling in mechanobiology
Volume
14
Pages
217-229
Publisher
Springer Berlin Heidelberg
Description
Ventricular growth is widely considered to be an important feature in the adverse progression of heart diseases, whereas reverse ventricular growth (or reverse remodeling) is often considered to be a favorable response to clinical intervention. In recent years, a number of theoretical models have been proposed to model the process of ventricular growth while little has been done to model its reverse. Based on the framework of volumetric strain-driven finite growth with a homeostatic equilibrium range for the elastic myofiber stretch, we propose here a reversible growth model capable of describing both ventricular growth and its reversal. We used this model to construct a semi-analytical solution based on an idealized cylindrical tube model, as well as numerical solutions based on a truncated ellipsoidal model and a human left ventricular model that was reconstructed from magnetic resonance images. We …
Total citations
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Scholar articles
LC Lee, M Genet, G Acevedo-Bolton, K Ordovas… - Biomechanics and modeling in mechanobiology, 2015