Authors
Children's Health Study (CHS) and HARBORS study Gilliland Frank D 4, Genetics of Asthma in Latino Americans (GALA) Study, the Study of Genes-Environment and Admixture in Latino Americans (GALA2) and the Study of African Americans, Asthma, Genes & Environments (SAGE) Burchard Esteban G 5 15, Childhood Asthma Research and Education (CARE) Network Martinez Fernando D 6, Childhood Asthma Management Program (CAMP) Weiss Scott T 7, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE) Williams L Keoki 35, Genetic Research on Asthma in the African Diaspora (GRAAD) Study Barnes Kathleen C 9, Carole Ober, Dan L Nicolae
Publication date
2011/9
Journal
Nature genetics
Volume
43
Issue
9
Pages
887-892
Publisher
Nature Publishing Group US
Description
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10−9). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when …
Total citations
Scholar articles
Children's Health Study (CHS) and HARBORS study … - Nature genetics, 2011