Authors
Maria Pino-Yanes, Neeta Thakur, Christopher R Gignoux, Joshua M Galanter, Lindsey A Roth, Celeste Eng, Katherine K Nishimura, Sam S Oh, Hita Vora, Scott Huntsman, Elizabeth A Nguyen, Donglei Hu, Katherine A Drake, David V Conti, Andres Moreno-Estrada, Karla Sandoval, Cheryl A Winkler, Luisa N Borrell, Fred Lurmann, Talat S Islam, Adam Davis, Harold J Farber, Kelley Meade, Pedro C Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A Lenoir, Jean G Ford, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Shannon M Thyne, Saunak Sen, Jose R Rodriguez-Santana, Carlos D Bustamante, L Keoki Williams, Frank D Gilliland, W James Gauderman, Rajesh Kumar, Dara G Torgerson, Esteban G Burchard
Publication date
2015/1/1
Journal
Journal of Allergy and Clinical Immunology
Volume
135
Issue
1
Pages
228-235
Publisher
Mosby
Description
Background
Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.
Objective
To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.
Methods
We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.
Results
Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P …
Scholar articles
M Pino-Yanes, N Thakur, CR Gignoux, JM Galanter… - Journal of Allergy and Clinical Immunology, 2015