Authors
Laramie E Duncan, Andrew Ratanatharathorn, Allison E Aiello, Lynn M Almli, Ananda B Amstadter, Allison E Ashley-Koch, Dewleen G Baker, Jean C Beckham, Laura J Bierut, Jonathan Bisson, Bekh Bradley, Chia-Yen Chen, Shareefa Dalvie, Lindsay A Farrer, Sandro Galea, Melanie E Garrett, Joel E Gelernter, Guia Guffanti, Michael A Hauser, Eric O Johnson, Ronald C Kessler, Nathan A Kimbrel, Anthony King, Nastassja Koen, Henry R Kranzler, Mark W Logue, Adam X Maihofer, Alicia R Martin, Mark W Miller, Rajendra A Morey, Nicole R Nugent, John P Rice, Stephan Ripke, Andrea L Roberts, Nancy L Saccone, Jordan W Smoller, Dan J Stein, Murray B Stein, Jennifer A Sumner, Monica Uddin, Robert J Ursano, Derek E Wildman, Rachel Yehuda, Hongyu Zhao, MJ Daly, I Liberzon, KJ Ressler, CM Nievergelt, KC Koenen
Publication date
2018/3
Journal
Molecular psychiatry
Volume
23
Issue
3
Pages
666-673
Publisher
Nature Publishing Group
Description
The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h 2 SNP) for European-American females of 29% that is similar to h 2 SNP for schizophrenia and is substantially higher than h 2 SNP in European-American males (estimate not distinguishable from zero). We found strong evidence of overlapping genetic risk between PTSD and schizophrenia along with more modest evidence of overlap with bipolar and major depressive disorder. No single-nucleotide polymorphisms (SNPs) exceeded genome-wide significance in the …
Scholar articles
LE Duncan, A Ratanatharathorn, AE Aiello, LM Almli… - Molecular psychiatry, 2018