Authors
A Gordon Robertson, Juliann Shih, Christina Yau, Ewan A Gibb, Junna Oba, Karen L Mungall, Julian M Hess, Vladislav Uzunangelov, Vonn Walter, Ludmila Danilova, Tara M Lichtenberg, Melanie Kucherlapati, Patrick K Kimes, Ming Tang, Alexander Penson, Ozgun Babur, Rehan Akbani, Christopher A Bristow, Katherine A Hoadley, Lisa Iype, Matthew T Chang, Mohamed H Abdel-Rahman, Adrian Ally, J Todd Auman, Miruna Balasundaram, Saianand Balu, Christopher Benz, Rameen Beroukhim, Inanc Birol, Tom Bodenheimer, Jay Bowen, Reanne Bowlby, Denise Brooks, Rebecca Carlsen, Colleen M Cebulla, Andrew D Cherniack, Lynda Chin, Juok Cho, Eric Chuah, Sudha Chudamani, Carrie Cibulskis, Kristian Cibulskis, Leslie Cope, Sarah E Coupland, Timothy Defreitas, John A Demchok, Laurence Desjardins, Noreen Dhalla, Bita Esmaeli, Ina Felau, Martin L Ferguson, Scott Frazer, Stacey B Gabriel, Julie M Gastier-Foster, Nils Gehlenborg, Mark Gerken, Jeffrey E Gershenwald, Gad Getz, Klaus G Griewank, Elizabeth A Grimm, D Neil Hayes, Apurva M Hegde, David I Heiman, Carmen Helsel, Shital Hobensack, Robert A Holt, Alan P Hoyle, Xin Hu, Carolyn M Hutter, Martine J Jager, Stuart R Jefferys, Corbin D Jones, Steven JM Jones, Cyriac Kandoth, Katayoon Kasaian, Jaegil Kim, Raju Kucherlapati, Eric Lander, Michael S Lawrence, Alexander J Lazar, Semin Lee, Kristen M Leraas, Pei Lin, Jia Liu, Wenbin Liu, Laxmi Lolla, Yiling Lu, Yussanne Ma, Harshad S Mahadeshwar, Odette Mariani, Marco A Marra, Michael Mayo, Sam Meier, Shaowu Meng, Matthew Meyerson, Piotr A Mieczkowski, Gordon B Mills, Richard A Moore, Lisle E Mose, Andrew J Mungall, Bradley A Murray, Rashi Naresh, Michael S Noble, Angeliki Pantazi, Michael Parfenov, Peter J Park, Joel S Parker, Charles M Perou, Todd Pihl, Robert Pilarski, Alexei Protopopov, Amie Radenbaugh, Karan Rai, Nilsa C Ramirez, Xiaojia Ren, Sheila M Reynolds, Jeffrey Roach, Sergio Roman-Roman, Jason Roszik, Sara Sadeghi, Gordon Saksena, Xavier Sastre, Dirk Schadendorf, Jacqueline E Schein, Lynn Schoenfield, Steven E Schumacher, Jonathan Seidman, Sahil Seth, Geetika Sethi, Margi Sheth, Yan Shi, Carol Shields, Ilya Shmulevich, Janae V Simons, Arun D Singh, Payal Sipahimalani, Tara Skelly, Heidi Sofia, Matthew G Soloway, Xingzhi Song, Marc-Henri Stern, Joshua Stuart, Qiang Sun, Huandong Sun, Angela Tam, Donghui Tan, Jiabin Tang, Roy Tarnuzzer, Barry S Taylor, Nina Thiessen
Publication date
2017/8/14
Journal
Cancer cell
Volume
32
Issue
2
Pages
204-220. e15
Publisher
Elsevier
Description
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-UM. Poor-prognosis M3-UM divide into subsets with divergent genomic aberrations, transcriptional features, and clinical outcomes. We report change-of-function SRSF2 mutations. Within D3-UM, EIF1AX- and SRSF2/SF3B1-mutant tumors have distinct somatic copy number alterations and DNA methylation profiles, providing insight into the biology of these low- versus intermediate-risk clinical mutation subtypes.
Scholar articles
AG Robertson, J Shih, C Yau, EA Gibb, J Oba… - Cancer cell, 2017